{"id":3794,"date":"2018-09-21T11:48:03","date_gmt":"2018-09-21T10:48:03","guid":{"rendered":"http:\/\/blogak.goiena.eus\/elexpuru\/?p=3794"},"modified":"2019-01-05T10:54:21","modified_gmt":"2019-01-05T09:54:21","slug":"ikerketa-berri-batek-sardiniarren-eta-euskaldunen-antz-genetikoa-azpimarratzen-du","status":"publish","type":"post","link":"https:\/\/blogak.goiena.eus\/elexpuru\/2018\/09\/21\/ikerketa-berri-batek-sardiniarren-eta-euskaldunen-antz-genetikoa-azpimarratzen-du\/","title":{"rendered":"Ikerketa berri batek sardiniarren eta euskaldunen antz genetikoa azpimarratzen du"},"content":{"rendered":"

Ez da lehena. 2017an argitaratu zen “Mitogenome Diversity in Sardinians: a Genetic Window onto an Island’s past<\/em><\/a>“, Anna Olivieri<\/a> Paviako Unibertsitateko genetistak zuzendu eta munduko hamahiru  unibertsitate edo ikerketa-etxeko hogeita hamabi ikerlek sinaturiko lana. Oxfordeko unibertsitateak atera zuen hura.<\/p>\n

2018ko irailekoa da oraingoa. “Genomic history of the Sardinian population<\/a>” du izena. Estatu Batuetako eta Sardiniako unibertsitateetako 17 ikerlek sinatzen dute eta Nature aldizkari prestigiotsuak argitaratu du. Sardiniako 3.514 pertsonaren mostrak erabili dituzte. Pdf-a eskuratu ahal izan dugu.  Horrela hasten da:<\/p>\n

“The population of the Mediterranean island of Sardinia has made important contributions to genome-wide association studies of complex disease traits and, based on ancient DNA studies of mainland Europe, Sardinia is hypothesized to be a unique refuge for early Neolithic ancestry. To provide new insights on the genetic history of this flagship population, we analyzed 3,514 wholegenome sequenced individuals from Sardinia. Sardinian samples show elevated levels of shared ancestry with Basque individuals,
\nespecially samples from the more historically isolated regions of Sardinia”.<\/p>\n

Beste pasarte batzuk:<\/p>\n

“Sardinia in relation to other Mediterranean populations. Due to
\nits smaller long-term effective population size (Fig. 5b), Sardinia is
\nexpected to have undergone accelerated genetic drift. To correct for
\nthis when measuring similarity to other mainland populations, we
\nused the \u2018shared drift\u2019 outgroup-f3 statistics62, which measures the
\nlength of shared branch length between two populations relative
\nto an outgroup. Using this metric, we find that the Basque are the
\nmost similar to Sardinia, even more so than mainland Italian populations
\nsuch as Tuscan and Bergamasque (Supplementary Fig. 6a,b).
\nWe also tested the affinity between Sardinians and Basque with the
\nD-statistics of the form D(Outgroup, Sardinia; Bergamo or Tuscan,
\nBasque). In this formulation, significant allele sharing between
\nSardinia and Basque, relative to sharing between Sardinia and
\nItalian populations, will result in positive values for the D-statistics.
\nSardinia consistently showed increased sharing with the Basque
\npopulations compared to mainland Italians (Z > 4; Supplementary
\nFig. 6c). The result was stronger when using the Arzana than
\nthe Cagliari sample (D(Outgroup, Basque, CAG, ARZ) = 0.0020
\nand 0.0021 for French Basque and Spanish Basque, respectively;
\nZ > 3.2). In contrast, sharing with other Spanish samples was generally
\nweaker and not significant (Supplementary Fig. 6c), suggesting
\nthe shared drift with the Basque is not mediated through modern
\nSpanish ancestry”. […]<\/p>\n

“We found Sardinians show a signal of shared ancestry with
\nthe Basque in terms of the outgroup f3 shared-drift statistics. This
\nis consistent with long-held arguments of a connection between
\nthe two populations, including claims of Basque-like, non-Indo-
\nEuropean words among Sardinian placenames64. More recently, the
\nBasque have been shown to be enriched for Neolithic farmer ancestry21,46
\nand Indo-European languages have been associated with
\nsteppe population expansions in the post-Neolithic Bronze Age19,24.
\nThese results support a model in which Sardinians and the Basque
\nmay both retain a legacy of pre-Indo-European Neolithic ancestry46.
\nTo be cautious, while it seems unlikely, we cannot exclude that the
\ngenetic similarity between the Basque and Sardinians is due to an
\nunsampled pre-Neolithic population that has affinities with the
\nNeolithic representatives analyzed here”.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ez da lehena. 2017an argitaratu zen “Mitogenome Diversity in Sardinians: a Genetic Window onto an Island’s past“, Anna Olivieri Paviako Unibertsitateko genetistak zuzendu eta munduko hamahiru  unibertsitate edo ikerketa-etxeko hogeita hamabi ikerlek sinaturiko lana. Oxfordeko unibertsitateak atera zuen hura. 2018ko … Jarraitu irakurtzen →<\/span><\/a><\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3794","post","type-post","status-publish","format-standard","hentry","category-sailkatugabeak"],"_links":{"self":[{"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/posts\/3794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/comments?post=3794"}],"version-history":[{"count":4,"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/posts\/3794\/revisions"}],"predecessor-version":[{"id":3980,"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/posts\/3794\/revisions\/3980"}],"wp:attachment":[{"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/media?parent=3794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/categories?post=3794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogak.goiena.eus\/elexpuru\/wp-json\/wp\/v2\/tags?post=3794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}